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Having a therapy that has been shown to address multiple symptoms of Rett syndrome provides a promising treatment option that may lead to meaningful impact for patients and their families. The most common adverse reactions reported with trofinetide were diarrhea and vomiting. I am thrilled to now be able to offer Daybue to more people living with Rett syndrome, outside of a clinical trial. Findings showed that treatment with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints).

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